2016年度中医内科学重点实验室顺利通过了教育部五年定期评估，成绩良好。

本年度重点实验室发表学术论文共计66篇，其中SCI收录合计34篇，第一作者或通讯作者单位31篇，影响因子合计 83.667，单篇最高影响因子 16.440；中文期刊发表论文合计31篇，核心期刊收录31篇。

新的一年，开局良好，我们将砥砺向前，撸起袖子加油干！

英文文章

1.心血管病方向

[1] Chen JianXin^#, XuXue^#, Li ZhongFeng^#, Gao Kuo^#, Zhang FeiLong,Li ZhiHong, Wang Xian, Shang HongCai*.Qishen Yiqi Drop Pill improves cardiac function after myocardial ischemia. Scientific Reports, 2016, 6: 24383.（SCI收录，IF5.228）

[2] Jianling Liu^#,Jiexin Mu^#, Chunli Zheng, Xuetong Chen, Zihu Guo, Chao Huang,Yingxue Fu, Guihua Tian, Hongcai Shang*,Yonghua Wang*. Systems-Pharmacology Dissection of Traditional Chinese MedicineCompound Saffron Formula Reveals Multi-scale Treatment Strategy for CardiovascularDiseases. Scientific Reports, 2016,6: 19809.（SCI收录，IF5.228）

[3]DongmeiZhang^#, Songbo Chai^#, Meng Chen, Aiming Wu, LixiaLou, Mingjing Zhao, Yonghong Gao, Limin Chai, Xiying Lv, Yikun Sun, ShuorenWang. The correlation between ventricular remodeling and arrhythmia in rat withmyocardial infarction[J].Int J Clin ExpMed.2016,9(2):1986-96. （SCI收录，IF1.075）

2.脑血管病方向

[4]Gui-Hua Tian, Shan-ShanTao, Man-Tang Chen, Yu-Sang Li, You-Ping Li, Hong-Cai Shang, Xiao-Yi Tang,Jian-Xin Chen and He-Bin Tang. Electroacupuncture Treatment Alleviates CentralPoststroke Pain by Inhibiting Brain Neuronal Apoptosis and Aberrant AstrocyteActivation[J]. Neural Plasticity, 2016, 2016: 1-14 （SCI收录，IF 3.568）

[5]  XiaoweiShi^#, WenjingYu^#,TiantianYang, WeiLiu, YizhouZhao, YikunSun, Limin Chai, YonghongGao, BinDong, LingqunZhu*. Panax notoginseng saponinsprovide neuroprotection by regulating NgR1/RhoA/ROCK2 pathway expression, invitro and in vivo. Journal ofEthnopharmacology, 2016, 190: 301-312.（SCI收录，IF 3.055）

[6]Xiaowei Shi^#,Wenjing Yu^#, Lixing Liu, Wei Liu, Xiaomeng Zhang, Tiantian Yang,Limin Chai, Lixia Lou, Yonghong Gao, LingqunZhu*. Panax notoginseng saponins administration modulates pro-/anti-inflammatory factor expression and improves neurologic outcome followingpermanent MCAO in rats[J]. MetabolicBrain Disease, 2016:1-13.（SCI收录，IF2.603）

[7]  Lijun Wu^#, Hua Zhang^#,Yanwei Xing^#, Yonghong Gao*,Yanda Li, Xiaomeng Ren, Jie Li, Bo Nie, Lingqun Zhu, Hongcai Shang, and YingGao. Meta-Analysis of the Effects of Xingnaojing Injection on ConsciousnessDisturbance. Medicine, 2016, 95(7):1-9.（SCI收录，IF2.133）

[8]Jing Shi^#,Xuekai Zhang^#, Long Yin, Mingqing Wei, Jingnian Ni, Ting Li, PengwenWang, Jinzhou Tian* and Yongyan Wang. Herbal formula GAPT prevents beta amyloiddeposition induced Ca2+/Calmodulin-dependent protein kinase II andCa2+/Calmodulin-dependent protein phosphatase 2B imbalance in APPV717I mice.BMC Complementary and Alternative Medicine, 2016, 16(1): 1-11.（SCI收录，IF1.987）

[9]  Kegang Cao^#, Fang Han^#,Anji Lin, Wenming Yang, Jianjun Zhao, Hui Zhang, Yanbing Ding, Wei Xie,YinpingXu, Tingmin Yu, Xinzhi Wang, Xiaosu Yang, Jiying Zhou, Qun Hou, Lihua Yu andYing Gao*. Zhengtian Capsule versus flunarizine in patients with migraine: amulti-center, double-blind, double-dummy, randomized controlled, non-inferiorclinical trial:[J]. BMC Complementary andAlternative Medicine, 2016, 16(1):356.（SCI收录，IF 1.987）

[10] JinzhouTian*, Jing Shi^#, Mingqing Wei^#, Renan Qin, JingnianNi, Xuekai Zhang, Ting Li,  Yongyan Wang.The efficacy and safety of Fufangdanshen tablets (Radix Salviae miltiorrhizaeformula tablets) for mild to moderate vascular dementia: a study protocol for arandomized controlled trial[J]. Trials,2016, 17(1):1-9.（SCI收录，IF1.859）

[11] Hui-li Feng,Hui-zi Dang, Hui Fan, Xiao-pei Chen, Ying-xue Rao, Ying Ren, Jin-duo Yang, JingShi, Peng-wen Wang*, Jin-zhou Tian.Curcumin ameliorates insulin signalling pathway in brain of Alzheimers diseasetransgenic mice. International Journal ofImmunopathology and Pharmacology, 2016, 29(4): 734-741.（SCI收录，IF1.617）

[12] Yingkun He, Pengwen Wang*, Peng Wei, Huili Feng,Ying Ren, Jinduo Yang, Yingxue Rao, Jing Shi, Jinzhou Tian. Effects of curcuminon synapses in APPswe/PS1dE9 mice. InternationalJournal of Immunopathology and Pharmacology,  2016, 29(2):217-225.（SCI收录，IF1.617）

[13] JinglingChang*, Hua Zhang, Zhongjian Tan, Juan Xiao, Shuren Li, Ying Gao. Effect ofelectroacupuncture in patients with post-stroke motor aphasia : Neurolinguisticand neuroimaging characteristics.[J]. WienerKlinische Wochenschrift, 2016, 9(2):1-8.（SCI收录，IF0.836）

3.临床评价方向

[14]Yaolong Chen, Kehu Yang*, Ana Marusˇic′,Amir Qaseem, Joerg J, Signe Flottorp, Elie A, Holger J, Edwin S.Y. Chan, YngveFalck-Ytter, Faruque Ahmed, Sarah Barber, Chiehfeng Chen, Mingming Zhang, BinXu, Jinhui Tian, Fujian Song, Hongcai Shang, Kun Tang, Qi Wang, Susan L.Norris*. A Reporting Tool for Practice Guidelines in Health Care: The RIGHTStatement.[J].Annals of Internal Medicine,2016,166(2):128-132. （SCI收录，IF16.440 ）

[15]Jingbo Zhai, Hongbo Cao, Ming Ren, Wei Mu, Sisi Lv, Jinhua Si, Hui Wang,

JingChen*, Hongcai Shang*. Reporting ofcore items in hierarchical Bayesian analysis for aggregating N-of-1 trials toestimate population treatment effects is suboptimal. Journal of Clinical Epidemiology, 2016, 76: 99-107.（SCI收录，IF4.703 ）

[16] Yinghui Jin, Guohao Wang,Yirong Sun, Qi Li, Chen Zhao, Ge Li,Jinhua Si, Yan Li, Cui Lu, Hongcai Shang*.A critical appraisal ofthe methodology and quality of evidence of systematic reviews and meta-analysisof traditionalChinese medical nursing interventions:a systematic review ofreviews [J]. BMJ Open. 2016,6:e011514 （SCI收录，IF 2.562 ）

[17] Ping Wang, Yuanlin Song,Zhi Liu, Hui Wang, Wenke Zheng, Si Liu, Zhiqiao Feng, Jingbo Zhai, Chen Yao,Ming Ren, Chunxue Bai* and Hongcai Shang*.Xuebijing injection in the treatment of severe pneumonia: study protocol for arandomized controlled trial. Trials, 2016, 17(1):1-11.（SCI收录，IF1.859 ）

[18] Yinghui Jin, Yunyun Wang,Yao Zhang, Yue Ma, Yan Li, Cui Lu, Wei Wang, Ge Li, Hongcai Shang*. Nursing Practice Guidelines in China do NeedReform: A Critical Appraisal Using the AGREE II Instrument. Worldviews Evid Based Nurs, 2016, 13(2):124-38. （SCI收录，IF 1.762 ）

[19]Fu SF^#, CW Cheng^#,L Zhang,LL Zhong,W Kun,J Lin, BL Zhang, YY Wang, HC Shang*,ZX Bian*. Consensus-based recommendations for case report in Chinese medicine(CARC).[J]. Chinese Journal ofIntegrative Medicine, 2016, 22(1):73-79.（SCI收录，IF1.224）

[20]Fu Shu-fei, Kun Wai, Zeng Xiao-xi, Zhang Li, Cheng Chung-wah, Song Lisa, ZhongLinda Li-dan, Lin Jia, Wang Yong-yan, ShangHong-cai*, Bian Zhao-xiang. Urgent need to improve the quality of casereport in traditional Chinese medicine: Assessment on reporting quality of3,417 cases. Chinese Journal ofIntegrative Medicine, 2016, 22(6): 473-480.（SCI收录，IF1.224）

[21]Li B, Gao HY, Gao R, Zhao YP, Li QN, Zhao Y, Tang XD*, Shang HC*.Joint Development of Evidence-Based Medical Record by Doctors and Patientsthrough Integrated Chinese and Western Medicine on Digestive System Diseases. Chinese Journal of Integrative Medicine,2016, 22(02): 83-87.（SCI收录，IF1.224）

[22]YE Yong-an*, TIAN De-lu, JIANG Jian, LI Jun, CHEN Jian-jie, LI Zhi-hong,MA Wei-guo, ZHAO Yi-ming, WANG Rong-bing, YANG Shi-zhong, SHAO Feng-zhen, JIGuang, ZHOU Da-qiao, LIU Tie-jun, CHENG Dong-sheng, ZHANG Wei, SUN Ke-wei, WANGYu-fen, MIN Le-quan,LI Xiao-ke. Effect of Shuanghu Qinggan Granule (双虎清肝颗粒)and Yigan Yiqi Jieyu Granule (乙肝益气解郁颗粒) plus lamivudine onchronic hepatitis B patients: A randomized double-blind placebo-controlledtrial[J]. Chinese Journal of IntegrativeMedicine, 2016,12(5):1-7.（SCI收录，IF1.224 ）

[23]Yang Y, Xie JF, Yu KJ, Yao C, Li JG, Guan XD, Yan J, Ma XC, Kang Y, Yang CS,Yao XQ, Shang HC, Qiu HB*, for CHESS Study Investigators.Epidemiological Study of Sepsis in China: Protocol of a Cross-sectional Survey.Chin Med J 2016;129:2967-73.（SCI收录，IF0.96 ）

[24]Hong-Cai Shang, Xiong-Zhi Wu,Rui-Jin Qiu, Ya-Han Wang, Yong-Yan Wang. Traditional Chinese medicine shouldnot be ignored during the development of precision medicine with Chinesecharacteristics[J]. Traditional MedicineResearch, 2016, 1(3):105-115

4.中药药理方向

[25] Wei Kevin Zhang^#,Hong-Wei Gu^#, Xiao-Jun Li, Yu-Sang Li, He-BinTang*, Gui-Hua Tian, Hong-Cai Shang*. The dark side of"the force" - lipid nanoparticles enhance the oncogenesis ofdiethylnitrosamine and result in liver cancer in mice.[J]. Nanomedicine: Nanotechnology Biology & Medicine, 2016.（SCI收录，IF 5.671 ）

[26]Xu Xue^#, Zhang Chao^#, Li PiDong, Zhang FeiLong, Gao Kuo,Chen JianXin*, Shang HongCai*. Drug-symptomnetworking: Linking drug-likeness screening to drug discovery. Pharmacological Research, 2016, 103:105-113.（SCI收录，IF4.816 ）

[27] Lu Shan, En-Xue Tao, Qing-HuiMeng, Wen-Xia Hou, Kang Liu,Hong-Cai Shang, Jin-Bao Tang*, Wei-Fen Zhang*.Formulation, optimization, and pharmacodynamic evaluation ofchitosan/phospholipid/β-cyclodextrin microspheres.[J]. Drug Design, Development and therapy, 2016, 10:417.（SCI收录，IF3.028 ）

[28] Zhiqin Ren^#,Bo Nie^#, Tong Liu, FeiYuan, Feng Feng, Yuan Zhang, Weie Zhou,

Xiuli Xu, MeiyiYao, Feng Zhang*. Simultaneous Determination of Coumarin and Its Derivatives inTobacco Products by Liquid Chromatography-Tandem Mass Spectrometry. Molecules, 2016, 21(11): 1511.（SCI收录，IF2.465 ）

[29]Yu-Sang Li, Chang-Long Leng, Man-Tang Chen, Wei Kevin Zhang, Xiao-Jun Li,He-Bin Tang*, Hong-Cai Shang* andLi-Hua Zhu*. Mouse hepatic neoplasm formation induced by trace level and lowfrequency exposure to diethylnitrosamine through β-catenin signalingpathway[J]. Toxicology Research, 2016,5:210-223.（SCI收录，IF2.161 ）

[30]Bo Nie, Xue Li, Yi Wei, Meng Chen,Jingwei Zhou, Lixia Lou, Bin Dong, Aiming Wu, Dongmei Zhang, Lingqun Zhu, JiuliZhao, and Limin Chai*. Xianfanghuomingyin, a Chinese Compound Medicine,Modulates the Proliferation and Differentiation of T Lymphocyte in aCollagen-Induced Arthritis Mouse Model. Evidence-BasedComplementary and Alternative medicine, 2016, 2016: 1-14.（SCI收录，IF1.931 ）

[31]Lixia Lou^#,Jingwei Zhou^#, Yujun Liu^#, Yi Wei#, Jiuli Zhao#, JiagangDeng, Bin Dong, Lingqun Zhu, Aiming Wu, Yingxi Yang and Limin Chai. Chlorogenicacid induces apoptosis to inhibit inflammatory proliferation of IL-6-inducedfibroblast-like synoviocytes through modulating the activation of JAK/STAT andNF-κB signaling pathways[J]. Experimental& Therapeutic Medicine,2016, 11(5): 2054 - 2060.（SCI收录，IF1.28 ）

[32] Wang Jing, LaiZong-lang, Chen Xin-yi, Li Dong-yun, Zhang Ya-yue, Ma Wei, Chu Yu-ting,Shi Feng-qin, Yang Lu, and Hou Li*. Effect of Compound Zhebei Granule(复方浙贝颗粒)Combinedwith Chemotherapy on Surface Markers of Leukemia Stem Cell in Patients withAcute Myeloid Leukemia[J]. ChineseJournal of Integrative Medicine, 2016, 22(6):1-7.（SCI收录，IF1.224）

[33]Peng Zhang^#, Bo Nie^#, Yan Li, Junhong Wang,Huiping Yu, Mian Sang. Clearing heat and promoting diuresis method on TGF-β1/Smadsignal pathway in airway remodeling of asthmatic rats[J].Int J Clin Exp Med,2016,9(12):23781-23789.（SCI收录，IF 1.075）

[34] Yuting Chu,Ling Zhang, Xiaoyu Zhu, Yayue Zhang, Bo Xia, Li Hou, Rushun Song, Tiantian Li,Chunqi Li, Qing Dong*, Xinyi Chen*. Investigation of hemostatic effectof Spleen-invigorating, Qi-replenishing and Blood-arresting Formula onsimvastatin-induced zebrafish hemorrhage model[J]. Journal of Traditional Chinese Medical Sciences, 2016,9（4）:1-8.（SCI收录，IF0.608）

[35] Haiyan Lang,Ming Guo, Yuting Chu, Wei Ma, YaYue Zhang, Ling Zhang*, Xinyi Chen*.Study of establishing disease-syndrome combined with animal model for immunethrombocytopenic purpura without additional conditions[J]. Journal of Traditional Chinese Medical Sciences, 2016,9（3）:1-6.（SCI收录，IF0.608）

备注：#：共同第一作者；*：通讯作者

中文文章

1.心血管病方向

[1] 吴爱明,娄利霞, 张冬梅,等. 氧化低密度脂蛋白胆固醇及相关因素与高血压并发脑梗死的相关性分析[J]. 中西医结合心脑血管病杂志, 2016, 14(20):2353-2355.

[2] 吴爱明，娄利霞，陈萌，等.生脉注射液和血塞通注射液对H9c2心肌细胞Cx43表达及凋亡的影响[J]. 中西医结合心脑血管病杂志, 2016，16( 34) : 6601-6605．

[3] 张冬梅,吴爱明, 娄利霞,等. 扶正化瘀胶囊对心肌梗死大鼠Rock1、Rock2表达的影响[J]. 中国中医药信息杂志, 2016, 23(9):74-77.

[4] 杨涛,赵明镜, 王蕾,等. “心主神明”的内涵及现代科学依据[J]. 北京中医药大学学报, 2016, 39(10)：811-814.

[5] 杨瑞薛,赵明镜, 雷环,等. 益气活血解毒方对血管损伤后外膜早期炎症和血管重构的影响[J]. 中西医结合心脑血管病杂志, 2016, 14(19):2230-2235.

[6] 鹿小燕,高永红, 李耿,等. 痰瘀型代谢综合征合并冠心病病人脂联素和胰岛素抵抗的关系[J]. 中西医结合心脑血管病杂志, 2016, 14(10):1057-1060.

[7] 郑瑞玲,陈萌, 吴爱明,等. 活血益气方及其拆方对大鼠心肌梗死边缘区血管内皮生长因子及其上游调控因子miR-126的影响[J]. 中医杂志, 2016, 57(12):1061-1064.

[8] 刘硕,李敏, 陈诗琪,等. 中成药改善慢性心衰患者左室射血分数与脑钠肽水平的系统评价和Meta分析[J]. 上海大学学报自然科学版, 2016, 22(3):357-365.

2.脑血管病方向

[9] 吴丽君,任晓萌, 孙逸坤,等. 醒脑静注射液治疗缺血性脑梗死研究进展[J]. 国际中医中药杂志, 2016, 38(7):667-669.

[10]   王蕾,赵明镜,杨涛,等.氨基酸类神经递质与认知活动关系及中医药应用的研究进展[J].中医药导报,2016.

[11] 董云芳,冯慧利, 何瑛琨,等. 姜黄素对小鼠海马Aβ生成酶和降解酶的影响[J]. 北京中医药大学学报, 2016, 39(3):230-234.

[12] 双梅,商洪才. 蒙医放血疗法治疗血管性头痛的临床研究[J]. 内蒙古医科大学学报, 2016, 38(4):335-340.

3.临床评价方向

[13] 翟静波,曹红波, 王晓辉,等. 基于关联规则的大学生“上火”相关核心生活习惯分析[J]. 中华中医药杂志, 2016(7):2552-2555.

[14] 赵晨,李戈, 思金华,等. 基于文献探讨中医证候演变规律研究的设计形式和要素[J]. 中华中医药杂志, 2016(5):1914-1919.

[15] 李艳,陈耀龙,陈静,等. 心肌梗死二级预防非药物措施患者指南的研制思路[J]. 中国循证医学杂志,2016,05:617-620.

[16] 赵晨,思金华, 李戈,等. 针刺镇痛临床试验设置安慰对照的分析与反思[J]. 中华中医药杂志, 2016(4):1149-1153.

[17] 双梅,赵晨, 张莉,等. 运用SYRCLE工具评价中文期刊发表卒中/中风动物实验的方法学质量[J]. 中国循证医学杂志, 2016(5):592-597.

[18] 邱瑞瑾,高永红, 商洪才,等. 病络理论指导下脑、心、肾一体化中西医结合防治体系的构建[J]. 中医杂志, 2016, 57(5):361-365.

[19] 翟静波,王晓辉, 曹红波,等. 大学生“上火”症状特点的关联规则分析[J]. 天津中医药, 2016(8):462-464.

[20] 王家莹,田贵华, 张莉,等. 中医药系统评价/Meta分析结果的引证现状调查[J]. 兰州大学学报(医学版),2016, 42(1):48-54.

[21] 翟静波,李小江, 张鹤,等. 质量调整生存分析在中医药辅助治疗肿瘤疗效评价中的应用价值[J]. 中国新药杂志, 2016(8):899-902.

[22] 陈耀龙,周奇,崔荣荣,等. 基于AGREE Ⅱ的中医药临床指南质量评价[J]. 中国循证医学杂志,2016,11:1331-1337.

[23] 靳英辉,赵晨, 甘惠,等. 化疗性静脉炎护理干预效果的网状Meta分析[J]. 护理学杂志, 2016, 31(4):85-90.

[24] 苗鹏伟,张明妍, 张莉,等. 稳心颗粒治疗成人房性早搏的Meta分析[J]. 天津中医药大学学报, 2016,35(3):160-166.

[25] 雷翔,郑蕊, 李楠,等. 血必净注射液治疗重症肺炎系统评价的再评价[J]. 中国中西医结合急救杂志, 2016, 23(2):133-137.

4.中药药理方向

[26] 冯成,王硕仁, 张鹏,等. RP-HPLC测定八珍益母汤剂两种煎药方法芍药苷和阿魏酸的含量[J]. 中国现代中药, 2016, 18(5):640-643.

[27] 杨颖溪,柴立民, 吴甜甜,等. 补肾益肺消癥方对特发性肺纤维化大鼠Caspase-12信号通路关键分子基因和蛋白表达的影响[J]. 北京中医药大学学报, 2016, 39(7):575-579.

[28] 吴甜甜,柴立民, 杨颖溪,等. 补肾益肺消癥方干预肺纤维化大鼠JNK凋亡信号通路关键分子的表达调控内质网应激的作用机制[J]. 现代中西医结合杂志, 2016, 25(19):2053-2056.

[29] 丁劲,张耀圣, 商建伟,等. 益肾健脾方对少弱精子症小鼠模型睾丸生精功能和血清性激素水平的影响[J]. 环球中医药, 2016, 9(11).

[30] 雷文娟,张铿, 潘庆军,等. 原发性肾病综合征患者急性肾损伤标志物的检测及其意义[J]. 中国中西医结合肾病杂志, 2016, 17(6):499-501.

[31] 贺丰,俞兴, 穆晓红,等. 新型脊髓完全横断缺损模型大鼠的建立[J]. 中国组织工程研究, 2016, 20(5):635-639.